ceesdekker Can Be Fun For Anyone
ceesdekker Can Be Fun For Anyone
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‘Certainly, which is about ideal. I hunt for a Actual physical understanding of biological units inside a base-up way. I do think you can distinguish 3 strains of study in my group at this time. The initial problems chromosome framework: How does one obtain a metre-prolonged DNA polymer folded and organised in this kind of microscopic mobile? We've designed visualisation approaches that allow us to study how, such as, SMC proteins loop DNA (online video on Youtube) to be able to Construct up chromosomes.
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Like a human being, I provide the biblical assignment to explore and use everything in development for the good thing about my neighbour. I do not knowledge any conflict concerning religion and science. On the contrary, my faith stimulates me to complete science, to get open-minded on the planet.’
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
2010, created a whole new way (‘wedging transfer’) to control nanostructures; to start with report of DNA translocation through graphene nanopores; and realized hybrid nanopores by https://www.ceesdekker.net directed insertion of α-hemolysin into sound-condition nanopores
SMC complexes can go Actual physical roadblocks larger than their ring measurement, indicating a nontopological mechanism for DNA loop extrusion
We use nanofabricated microfluidic constructions to pattern spatial boundaries for microorganisms and biomimetic vesicles with reconstituted protein networks and this assess the fundamental role of spatial confinement at the molecular and mobile amount. Our jobs include things like the subsequent:
Dynamic ParB–DNA interactions initiate and sustain a partition condensate for bacterial chromosome segregation
What if, in lieu of employing standard top rated-down silicon electronics, transistors could possibly be built from The underside up using solitary organic molecules since the switching elements? This concept, which turned the basis of today’s subject of molecular electronics, initial emerged while in the 1970s.
There was a person problem although — we did not observe any measurable electrical conduction from The only polymer molecules. We concluded that at The only-molecule stage, conducting polymers ended up essentially not these types of great conductors, which was instead disappointing. We Therefore broadened our check out to try to locate a lot more promising molecules.
FtsZ treadmilling is important for Z-ring condensation and septal constriction initiation in bacterial cell division
2001, discovery of solitary-electron transistors at area temperature determined by nanotubes; realization of initially logic circuits with carbon nanotube equipment; and discovery of your molecular composition of DNA maintenance enzymes with AFM
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2013, managed shaping of Dwell bacterial cells into arbitrary styles; and discovery of spontaneous fluctuations while in the handedness of histone tetrasomes